The Rate and Tract Length of Gene Conversion between Duplicated Genes
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چکیده
منابع مشابه
The Rate and Tract Length of Gene Conversion between Duplicated Genes
Interlocus gene conversion occurs such that a certain length of DNA fragment is non-reciprocally transferred (copied and pasted) between paralogous regions. To understand the rate and tract length of gene conversion, there are two major approaches. One is based on mutation-accumulation experiments, and the other uses natural DNA sequence variation. In this review, we overview the two major appr...
متن کاملSpecial Issue: Gene Conversion in Duplicated Genes
Gene conversion is an outcome of recombination, causing non-reciprocal transfer of a DNA fragment. Several decades later than the discovery of crossing over, gene conversion was first recognized in fungi when non-Mendelian allelic distortion was observed. Gene conversion occurs when a double-strand break is repaired by using homologous sequences in the genome. In meiosis, there is a strong pref...
متن کاملNeofunctionalization of duplicated genes under the pressure of gene conversion.
Neofunctionalization occurs when a neofunctionalized allele is fixed in one of duplicated genes. This is a simple fixation process if duplicated genes accumulate mutations independently. However, the process is very complicated when duplicated genes undergo concerted evolution by gene conversion. Our simulations demonstrate that the process could be described with three distinct stages. First, ...
متن کاملThe effect of gene conversion on the divergence between duplicated genes.
Nonindependent evolution of duplicated genes is called concerted evolution. In this article, we study the evolutionary process of duplicated regions that involves concerted evolution. The model incorporates mutation and gene conversion: the former increases d, the divergence between two duplicated regions, while the latter decreases d. It is demonstrated that the process consists of three phase...
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ژورنال
عنوان ژورنال: Genes
سال: 2011
ISSN: 2073-4425
DOI: 10.3390/genes2020313